Gandapur A S, Malik S A, Raziq F
Department of Basic Medical Sciences, Gomal University, Dera Ismail Khan.
J Pak Med Assoc. 1997 May;47(5):137-9.
The bone marrow reports of 1966 patients admitted to a provincial teaching hospital between January, 1992 to April, 1995 were retrospectively analyzed. Twenty-six (1.3%) bone marrows showed the presence of malarial parasites. Sixteen (62%) patients had Plasmodium falciparum 9 (34%) Vivax malaria and one (4%) mixed infection. All these patients gave a history of prolonged illness and had low parasite counts. Plasmodium vivax malaria was not associated with any significant pathology in the bone marrow, except iron deficiency anaemia. The bone marrows with Plasmodium falciparum malaria showed myeloid hyperplasia, erythroid hyperplasia, megaloblastosis and hypoplasia in different proportions. No evidence of dyserythropoiesis was found in this series. The possible mechanisms producing these changes and the factors responsible for the discrepancy in bone marrow findings in different geographical areas are discussed.
对1992年1月至1995年4月间收入一所省级教学医院的1966例患者的骨髓报告进行了回顾性分析。26例（1.3%）骨髓显示有疟原虫。16例（62%）患者为恶性疟原虫感染，9例（34%）为间日疟原虫感染，1例（4%）为混合感染。所有这些患者均有长期患病史且疟原虫计数较低。除缺铁性贫血外，间日疟原虫感染未伴有骨髓任何显著病变。恶性疟原虫感染的骨髓呈现出不同比例的髓系增生、红系增生、巨幼样变和发育不全。本系列研究未发现红细胞生成异常的证据。讨论了产生这些变化的可能机制以及不同地理区域骨髓检查结果存在差异的相关因素。
