Sen R, Tewari A D, Sehgal P K, Singh U, Sikka R, Sen J
Medical College, Rohtak (Haryana), India.
J Commun Dis. 1994 Mar;26(1):31-8.
The clinicohaematological findings of acute state (Group A, 30 patients) and chronic state (Group B, 34 patients) of falciparum malaria in paediatric patients are compared. The children with chronic falciparum malaria were apyrexic and presented with features of moderate to severe anaemia with hepato-splenomegaly. Greater severity of anaemia and haemolysis, higher incidence and severity of neutropenia, atypical lymphocytosis, monocytosis and thrombocytopenia were observed in patients with chronic falciparum malaria as compared to patients with acute falciparum malaria despite lesser degree of parasitaemia in the former as compared to the latter. While mechanical destruction of parasitised RBC's, ineffective and dysplastic erythropoiesis either due to unmasking of border line dierty folic acid deficiency or otherwise, transient hypoplasia of bone marrow, impaired utilization of iron and immune destruction of RBCs with hypersplenism may be the mechanisms for anaemia, transient hypoplasia of bone marrow and hypersplenism may be the factors responsible for thrombocytopenia and neutropenia.
比较了小儿恶性疟急性状态（A组，30例患者）和慢性状态（B组，34例患者）的临床血液学检查结果。慢性恶性疟患儿无发热，表现为中度至重度贫血并伴有肝脾肿大。与急性恶性疟患者相比，慢性恶性疟患者贫血和溶血更严重，中性粒细胞减少、非典型淋巴细胞增多、单核细胞增多和血小板减少的发生率和严重程度更高，尽管前者的寄生虫血症程度低于后者。虽然被寄生红细胞的机械破坏、由于潜在的边缘性叶酸缺乏或其他原因导致的无效和发育异常的红细胞生成、骨髓短暂发育不全、铁利用受损以及红细胞的免疫破坏伴脾功能亢进可能是贫血的机制，但骨髓短暂发育不全和脾功能亢进可能是导致血小板减少和中性粒细胞减少的因素。
