Landers A T, Narotam P K, Govender S T, van Dellen J R
Department of Neurosurgery, University of Natal & Wentworth Hospital, South Africa.
Br J Neurosurg. 1997 Jun;11(3):191-5. doi: 10.1080/02688699746230.
Several meteorological variables have been linked with an altered incidence of cerebrovascular disease. In particular, we had noticed that, following abrupt changes in weather, patients with aneurysmal subarachnoid haemorrhage (SAH) often presented in groups. This study was undertaken to determine whether changes in barometric pressure would be an important factor. A retrospective analysis of a two year period was carried out. Daily mean, peak and trough atmospheric pressures had been recorded independently by a weather bureau. Of the 157 patients with SAH due to a berry aneurysm, confirmed by CT and angiography, 60 were entered into the study. Patients residing outside the weather bureau region (n = 86), or where there was uncertainty of their day of ictus (n = 11), were excluded. Daily peak to trough pressure changes and mean monthly pressure fluctuations showed no association with an increased risk of SAH. However, a significant relationship between the incidence of onset of symptoms indicative of a rupture of the aneurysm and a change in barometric mean pressure (BMP) of > 10 hectapascals from the previous day was found (p = 0.0247). The calculated odds ratio of sustaining a SAH with this associated BMP change was therefore 2.7 times with a risk of 1-13 times at a 95% confidence level (p = 0.035).
多个气象变量已被证明与脑血管疾病发病率的改变有关。特别是，我们注意到，在天气突然变化之后，动脉瘤性蛛网膜下腔出血（SAH）患者常常成群出现。本研究旨在确定气压变化是否为一个重要因素。我们进行了一项为期两年的回顾性分析。气象局独立记录了每日平均、最高和最低气压。在157例经CT和血管造影确诊为因浆果样动脉瘤导致SAH的患者中，60例纳入研究。居住在气象局区域外的患者（n = 86），或发病日期不确定的患者（n = 11）被排除。每日最高气压与最低气压的变化以及月平均气压波动与SAH风险增加均无关联。然而，发现动脉瘤破裂相关症状发作的发生率与前一天气压平均变化（BMP）> 10百帕之间存在显著关系（p = 0.0247）。因此，与这种相关BMP变化相关的发生SAH的计算比值比为2.7倍，在95%置信水平下风险为1 - 13倍（p = 0.035）。
