Smith K C
Centre for Preventive Medicine, Animal Health Trust, Newmarket, Suffolk, UK.
Vet J. 1997 May;153(3):253-68. doi: 10.1016/s1090-0233(97)80061-5.
Abortion or neonatal disease may follow infection with several alpha, beta and gamma-herpesviruses. The alpha-herpesvirus, equid herpesvirus-1 (EHV-1), causes single or epizootic abortions or neonatal deaths in equids, and the closely related virus EHV-4 causes sporadic equine abortions. In cattle, the alpha-herpesviruses, bovine herpesvirus-1 (infectious bovine rhinotracheitis virus) and bovine herpesvirus-5 (bovine encephalitis virus), and a gamma-herpesvirus, bovine herpesvirus-4, have all been implicated as causes of abortion. In pigs, suid herpesvirus-1 (SHV-1: pseudorabies virus), an alpha-herpesvirus, and SHV-2 (porcine cytomegalovirus), a beta-herpesvirus, each cause abortion or neonatal piglet losses. Caprine herpesvirus-1, canine herpesvirus and feline herpesvirus-1, all alpha-herpesviruses, cause abortions or neonatal deaths in goats, dogs and cats, respectively. This review discusses the pathogenesis, pathology and laboratory diagnosis of these herpesviral abortions and neonatal diseases, with an emphasis on experimental studies of each disease. Alternative reviews covering other aspects of each infection, such as the genetic and antigenic structure of the viruses, host immune responses and approaches to vaccination and disease control are indicated at appropriate points in the text.
感染几种α、β和γ疱疹病毒可能会导致流产或新生儿疾病。α疱疹病毒——马疱疹病毒1型（EHV-1），可导致马出现单发或流行性流产或新生儿死亡，而与之密切相关的病毒EHV-4会引发散发性马流产。在牛群中，α疱疹病毒——牛疱疹病毒1型（传染性牛鼻气管炎病毒）和牛疱疹病毒5型（牛脑炎病毒），以及γ疱疹病毒——牛疱疹病毒4型，都被认为是导致流产的原因。在猪群中，α疱疹病毒——猪疱疹病毒1型（SHV-1：伪狂犬病病毒）和β疱疹病毒——SHV-2（猪巨细胞病毒），均可导致流产或新生仔猪死亡。α疱疹病毒——山羊疱疹病毒1型、犬疱疹病毒和猫疱疹病毒1型，分别会导致山羊、犬和猫出现流产或新生儿死亡。本文综述了这些疱疹病毒性流产和新生儿疾病的发病机制、病理学及实验室诊断方法，重点介绍了每种疾病的实验研究。文中适当位置指出了涵盖每种感染其他方面内容的相关综述，如病毒的遗传和抗原结构、宿主免疫反应以及疫苗接种和疾病控制方法等。
