突触小泡内吞作用。
Synaptic vesicle endocytosis.
作者信息
Cremona O, De Camilli P
机构信息
Department of Cell Biology, Yale University School of Medicine, 295 Congress Avenue, New Haven, Connecticut 06510, USA.
出版信息
Curr Opin Neurobiol. 1997 Jun;7(3):323-30. doi: 10.1016/s0959-4388(97)80059-1.
PMID:9232811
Abstract
Exocytosis of synaptic vesicles is followed rapidly by reinternalization and recycling of their membranes. Recent studies have confirmed the key role of clathrin-mediated endocytosis in synaptic vesicle reformation and have identified new proteins that participate in this process. In addition, growing evidence suggests that lipids, primarily phosphoinositides, play an important role in synaptic vesicle recycling.
摘要
突触小泡胞吐后，其膜会迅速重新内化和循环利用。最近的研究证实了网格蛋白介导的内吞作用在突触小泡重塑中的关键作用，并鉴定出了参与这一过程的新蛋白质。此外，越来越多的证据表明，脂质，主要是磷酸肌醇，在突触小泡循环中起重要作用。
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