枕孢菌素，一种来自担子菌枕状鸟巢菌（Nidularia pulvinata (Schw.) Fr.）的新型生物活性代谢产物。

Pulvinatal, a novel bioactive metabolite from the basidiomycete Nidularia pulvinata (Schw.) Fr.

作者信息

Becker U, Erkel G, Kocksch G, Anke T, Sterner O

机构信息

Lehrbereich Biotechnologie, Universität Kaiserslautern, Germany.

出版信息

Z Naturforsch C J Biosci. 1997 May-Jun;52(5-6):313-8. doi: 10.1515/znc-1997-5-606.

DOI:10.1515/znc-1997-5-606

PMID:9232889

Abstract

Pulvinatal (1) was isolated from fermentations of Nidularia pulvinata as an inducer of differentiation of HL-60 promyelocytic leukemia cells. Its structure was elucidated by spectroscopic methods. In addition, N. pulvinata was found to produce 2,4,5-trihydroxy-6-methyl-benzenecarbaldehyde (2) and orsellinic acid (3). Pulvinatal exhibits weak antifungal and only marginal cytotoxic activities.

摘要

从豆包菌的发酵产物中分离出了豆包菌素（1），它是HL-60早幼粒细胞白血病细胞分化的诱导剂。通过光谱方法阐明了其结构。此外，还发现豆包菌能产生2,4,5-三羟基-6-甲基苯甲醛（2）和苔色酸（3）。豆包菌素表现出较弱的抗真菌活性，细胞毒性也很微弱。