Nitidon，一种来自担子菌亚门真菌亮黄绒盖牛肝菌（Junghuhnia nitida (Pers.: Fr.) Ryv.）的新型生物活性代谢产物。
Nitidon, a new bioactive metabolite from the basidiomycete Junghuhnia nitida (Pers.: Fr.) Ryv.
作者信息
Gehrt A, Erkel G, Anke T, Sterner O
机构信息
Lehrbereich Biotechnologie, Universität Kaiserslautern.
出版信息
Z Naturforsch C J Biosci. 1998 Jan-Feb;53(1-2):89-92. doi: 10.1515/znc-1998-1-216.
PMID:9528126
Abstract
Nitidon, a highly oxidised pyranone derivative produced by the basidiomycete Junghuhnia nitida, has been isolated and its biological activities evaluated. The structure was determined by spectroscopic methods. Nitidon exhibits antibiotic and cytotoxic activities and induces morphological and physiological differentiation of tumor cells at nanomolar concentrations.
摘要
尼替东是一种由担子菌亚门真菌亮黄绒盖牛肝菌产生的高度氧化的吡喃酮衍生物，已被分离出来并对其生物活性进行了评估。其结构通过光谱方法确定。尼替东具有抗菌和细胞毒性活性，并在纳摩尔浓度下诱导肿瘤细胞的形态和生理分化。
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