Moroz I, Parker L A, Siegel S
Department of Psychology, Wilfrid Laurier University, Waterloo, Ontario, Canada.
Exp Clin Psychopharmacol. 1997 May;5(2):119-22. doi: 10.1037//1064-1297.5.2.119.
The ability of ibogaine, injected 24 hr before amphetamine, to modify the establishment of amphetamine-induced place preference learning was assessed. A single injection of ibogaine blocked the establishment of amphetamine place preference after 1 or 2 conditioning trials, but it was less effective after 4 trials. The reduced effectiveness of ibogaine across multiple conditioning trials appears to be the result of the development of tolerance to ibogaine.
评估了在苯丙胺注射前24小时注射伊博格碱改变苯丙胺诱导的位置偏爱学习建立的能力。单次注射伊博格碱在1次或2次条件试验后可阻断苯丙胺位置偏爱的建立，但在4次试验后效果较差。伊博格碱在多次条件试验中效果降低似乎是对伊博格碱产生耐受性的结果。
