Peters F, Breckwoldt M
Dtsch Med Wochenschr. 1977 Dec 2;102(48):1754-8. doi: 10.1055/s-0028-1105572.
36 women with postpartal breast engorgement were treated with a single oral dose of 2.5 mg bromocriptine (Pravidel). Significant relief was recorded in 28 patients, 6 patients required a second dose of 2.5 mg bromocriptine, whereas 2 patients failed to respond. Antibiotics were at first avoided in the treatment of puerperal mastitis. 26 patients with all characteristics of breast inflammation were treated exclusively with bromocriptine: for 3 days 2.5 mg t.i.d., for the following 11 days 2.5 mg twice daily. The temperature dropped below 37C in 25 patients within 12-24 hours, tension and pain disappearing simultaneously. One patient did not respond after 36 hours, so that an antibiotic was administered additionally; in another patient who had been admitted to the hospital six days after the onset of the clinical symptoms of breast inflammation, bromocriptine failed to prevent abscess formation. The results indicate that in most cases of puerperal breast inflammation no antibiotics are required. Puerperal mastitis can be treated effectively by the exclusive administration of bromocriptine.
36名产后乳房胀痛的妇女单次口服2.5毫克溴隐亭(帕罗西汀)进行治疗。28名患者症状明显缓解,6名患者需要再服用一剂2.5毫克溴隐亭,而2名患者无反应。产褥期乳腺炎治疗初期避免使用抗生素。26名具有乳房炎症所有特征的患者仅用溴隐亭治疗:前3天每日3次,每次2.5毫克,接下来11天每日2次,每次2.5毫克。25名患者在12至24小时内体温降至37摄氏度以下,同时张力和疼痛消失。1名患者36小时后无反应,因此加用了抗生素;另1名患者在乳房炎症临床症状出现6天后入院,溴隐亭未能预防脓肿形成。结果表明,在大多数产褥期乳房炎症病例中不需要使用抗生素。产褥期乳腺炎仅用溴隐亭治疗即可有效。