Tonon G, Boyd K, Lecchi A, Lombardi R, Porcella A, Cattaneo M
Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Institute of Internal Medicine, IRCCS Ospedale Maggiore, Italy.
Haematologica. 1997 May-Jun;82(3):343-4.
Polycythemia and hyperhomocysteinemia are risk factors for thrombosis. Since red blood cells actively metabolize methionine to homocysteine, we investigated whether or not patients with polycythemia have increased plasma levels of homocysteine, which might contribute to their increased thrombotic risk. In ten patients with polycythemia, the plasma homocysteine levels were measured before phlebotomy, three days after the procedure and 1-2 months later. The baseline mean plasma homocysteine levels in patients (9.7 +/- 1.6 mumol/L [+/-SD]) did not differ significantly from that found in 30 sex- and age-matched healthy controls (12.2 +/- 6.9). Despite a fall in the patients' mean [+/-SD] hematocrit from 0.50 +/- 0.02 at baseline to 0.47 +/- 0.03 three days after phlebotomy (significant at 95%) and to 0.48 +/- 0.02 after 1 to 2 months (not significant), the mean plasma homocysteine levels did not change significantly (9.9 +/- 2.3 mumol/L at 3 days and 9.7 +/- 2.1 mumol/L at 1-2 months). It is unlikely that high plasma homocysteine levels contribute to the increased thrombotic risk of polycythemic patients.
红细胞增多症和高同型半胱氨酸血症是血栓形成的危险因素。由于红细胞可将蛋氨酸积极代谢为同型半胱氨酸，我们研究了红细胞增多症患者血浆同型半胱氨酸水平是否升高，这可能导致其血栓形成风险增加。对10例红细胞增多症患者在放血前、放血后3天以及1 - 2个月后测量血浆同型半胱氨酸水平。患者的基线平均血浆同型半胱氨酸水平（9.7±1.6μmol/L[±标准差]）与30名年龄和性别匹配的健康对照者（12.2±6.9）相比无显著差异。尽管患者的平均[±标准差]血细胞比容从基线时的0.50±0.02降至放血后3天的0.47±0.03（95%水平显著）以及1 - 2个月后的0.48±0.02（不显著），但平均血浆同型半胱氨酸水平无显著变化（3天时为9.9±2.3μmol/L，1 - 2个月时为9.7±2.1μmol/L）。血浆同型半胱氨酸水平升高不太可能导致红细胞增多症患者血栓形成风险增加。
