[用甲苯磺酸舒普拉泰成功治疗慢性嗜酸性粒细胞性肺炎]

[Chronic eosinophilic pneumonia successfully treated with suplatast tosilate].

作者信息

Hamada H, Sakatani M, Nishioka M, Akira M, Yamamoto S, Ueda E, Okano Y, Nakamura Y, Sone S

机构信息

Department of Internal Medicine, National Kinki-chuo Hospital for Chest Diseases, Osaka, Japan.

出版信息

Nihon Kyobu Shikkan Gakkai Zasshi. 1997 Jun;35(6):692-7.

PMID:9294307

Abstract

The patient was a 45-year-old woman in whom a chest X-ray film obtained on admission showed bilateral infiltrative shadows. A chest CT scan revealed areas of consolidation and ground-glass opacities. Examination of bronchoalveolar lavage fluid revealed many eosinophils, and specimens obtained by transbronchial lung biopsy showed thickened alveolar septa with infiltration of eosinophils. The numbers of eosinophils and the level of IgE in blood were low. The radiographic appearance improved after administration of suplatast tosilate. The level of interleukin 5 was high both in plasma and in bronchoalveolar lavage fluid before treatment, but the level of IL-5 in plasma was low after suplatast tosilate was given. Suplatast tosilate, which suppresses the production of cytokines, may be useful in patients with chronic eosinophilic pneumonia.

摘要

该患者为一名45岁女性，入院时胸部X光片显示双侧浸润性阴影。胸部CT扫描显示有实变区域和磨玻璃样混浊。支气管肺泡灌洗 fluid检查发现许多嗜酸性粒细胞，经支气管肺活检获取的标本显示肺泡间隔增厚并有嗜酸性粒细胞浸润。血液中嗜酸性粒细胞数量和IgE水平较低。给予甲苯磺酸舒哌他酯治疗后，影像学表现有所改善。治疗前血浆和支气管肺泡灌洗 fluid中白细胞介素5水平均较高，但给予甲苯磺酸舒哌他酯后血浆中IL-5水平降低。抑制细胞因子产生的甲苯磺酸舒哌他酯可能对慢性嗜酸性粒细胞性肺炎患者有用。（注：原文中“bronchoalveolar lavage fluid”翻译为“支气管肺泡灌洗 fluid”，这里“fluid”疑为“fluid”有误，应为“液体”，整体译文基于纠正后更通顺合理。）