Esterre P, Guerret S, Ravisse P, Dimier-David L, Dedet J P, Grimaud J A
Immunology Unit, Institut Pasteur de Madagascar, Antananarivo, Madagascar.
Parasite. 1994 Dec;1(4):305-9. doi: 10.1051/parasite/1994014305.
Using antibodies against surface antigens of inflammatory cells and against extra-cellular matrix components, immunocytochemical studies permit the investigation of the in situ cellular immune response and the associated fibrosis, in mucosal lesions. 57 paraffin embedded skin biopsies of mucocutaneous leishmaniasis originating from Bolivia, and due to Leishmania (Viannia) braziliensis, were studied. Memory T cells predominate within a non-organized granulomatous reaction, in which were observed proliferating macrophages. At the top of the lesion, epithelial cells expressed HLA-DR. Some characteristics of this lesion, particularly its chronic destructive pattern, presently lack any clear explanation.
利用针对炎症细胞表面抗原和细胞外基质成分的抗体，免疫细胞化学研究能够对黏膜病变中的原位细胞免疫反应及相关纤维化进行研究。我们对57例源自玻利维亚、由巴西利什曼原虫（维氏亚属）引起的皮肤黏膜利什曼病石蜡包埋皮肤活检标本进行了研究。在无组织的肉芽肿反应中，记忆T细胞占主导地位，其中可见增殖的巨噬细胞。在病变顶部，上皮细胞表达HLA-DR。该病变的一些特征，尤其是其慢性破坏模式，目前尚无明确解释。
