Blood flow in normal and cholestatic dog liver as measured by intraparenchymal injection of Xenon 133.

Parenchymal liver blood flow as reflected by the wash-out of intraparenchymally injected 133Xe was studied at different stages of total cholestasis in the dog. 248 registrations at 13 laparotomies in 6 mongrel dogs showed that extrahepatic cholestasis had no statistically significant influence on the blood flow as compared to normal. A review of the literature shows little harmony between the results of this and various other studies.