Thorne J, Bennett R, Shields R, Johnson J, Taylor I
Br J Surg. 1979 Jun;66(6):385-8. doi: 10.1002/bjs.1800660604.
Measurement of liver blood flow has been carried out by three different methods in 14 dogs to assess the accuracy of xenon-133 clearance following portal vein injection. Electromagnetic flowmetry with flow probes on the hepatic artery and portal vein resulted in a mean value of 121.9 +/- 39.3 ml min-1 100 g-1. An indicator dilution study utilizing chromium-51-labelled red cells gave a mean value of 119.4 +/- 31.4 ml min-1 100 g-1 and the xenon-133 clearance following portal vein injection, 120.3 +/- 33.8 ml min-1 100 g-1. One-way analysis of variance showed no statistically significant variation between these three groups. There was a close correlation between xenon-133 clearance and electromagnetic flowmetry and between xenon-133 clearance and the indicator dilution technique. These data suggest that xenon-133 clearance following portal vein injection gives an accurate assessment of liver blood flow and this technique (as well as direct parenchymal injection) can be adapted for clinical use.
在14只狗身上采用三种不同方法测量肝血流量，以评估门静脉注射后氙-133清除率的准确性。在肝动脉和门静脉上使用流量探头进行电磁血流测量，得出的平均值为121.9±39.3毫升·分钟⁻¹·100克⁻¹。利用铬-51标记红细胞进行的指示剂稀释研究得出的平均值为119.4±31.4毫升·分钟⁻¹·100克⁻¹，门静脉注射后的氙-133清除率为120.3±33.8毫升·分钟⁻¹·100克⁻¹。单因素方差分析显示这三组之间无统计学显著差异。氙-133清除率与电磁血流测量之间以及氙-133清除率与指示剂稀释技术之间存在密切相关性。这些数据表明门静脉注射后的氙-133清除率能准确评估肝血流量，且该技术（以及直接实质内注射）可适用于临床。
