Bcl6基因的破坏导致生发中心形成受损。
Disruption of the Bcl6 gene results in an impaired germinal center formation.
作者信息
Fukuda T, Yoshida T, Okada S, Hatano M, Miki T, Ishibashi K, Okabe S, Koseki H, Hirosawa S, Taniguchi M, Miyasaka N, Tokuhisa T
机构信息
Division of Developmental Genetics, Center for Biomedical Science, Chiba University School of Medicine, Chiba, Japan.
出版信息
J Exp Med. 1997 Aug 4;186(3):439-48. doi: 10.1084/jem.186.3.439.
The Bcl6 gene has been identified from the chromosomal translocation breakpoint in B cell lymphomas, and its products are expressed highly in germinal center (GC) B cells. To investigate the function of Bcl6 in lymphocytes, we have generated RAG1-deficient mice reconstituted with bone marrow cells from Bcl6-deficient mice (Bcl6(-/-)RM). Lymphogenesis in primary lymphoid tissues of Bcl6(-/-)RM is normal, and Bcl6(-/-)RM produced control levels of primary IgG1 antibodies specific to T cell-dependent antigens. However, GCs were not found in these mice. This defect was mainly due to the abnormalities of B cells. Therefore, Bcl6 is essential for the differentiation of GC B cells.
Bcl6基因是从B细胞淋巴瘤的染色体易位断点中鉴定出来的，其产物在生发中心（GC）B细胞中高度表达。为了研究Bcl6在淋巴细胞中的功能，我们构建了用Bcl6基因缺陷小鼠（Bcl6(-/-)RM）的骨髓细胞重建的RAG1缺陷小鼠。Bcl6(-/-)RM初级淋巴组织中的淋巴细胞生成正常，并且Bcl6(-/-)RM产生的针对T细胞依赖性抗原的初级IgG1抗体水平与对照组相当。然而，在这些小鼠中未发现生发中心。这种缺陷主要是由于B细胞的异常所致。因此，Bcl6对于GC B细胞的分化至关重要。
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