Pharmacokinetics of methyldopa in healthy man.

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作者信息

Stenbaek O, Myhre E, Rugstad H E, Arnold E, Hansen T

出版信息

Eur J Clin Pharmacol. 1977 Oct 14;12(2):117-23. doi: 10.1007/BF00645132.

DOI:10.1007/BF00645132

PMID:923625

Abstract

摘要

相似文献

Pharmacokinetics of methyldopa in healthy man.

Eur J Clin Pharmacol. 1977 Oct 14;12(2):117-23. doi: 10.1007/BF00645132.

Pharmacokinetics of methyldopa in man.

J Pharmacol Exp Ther. 1976 Aug;198(2):264-77.

The pharmacokinetics of alpha-methyldopa in dogs.

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Conjugation of methyldopa in renal failure.

Scand J Clin Lab Invest. 1972 Apr;29(2):195-9. doi: 10.3109/00365517209081075.

Pharmacokinetics and presystemic gut metabolism of methyldopa in healthy human subjects.

J Clin Pharmacol. 1995 Mar;35(3):275-80. doi: 10.1002/j.1552-4604.1995.tb04058.x.

The renal excretion of methyldopa.

Scand J Clin Lab Invest. 1972 Apr;29(2):201-4. doi: 10.3109/00365517209081076.

Pharmacokinetics of methyldopa. Plasma levels following single intravenous, oral and multiple oral dosage in normotensive and hypertensive subjects.

Clin Exp Pharmacol Physiol. 1977 Jul-Aug;4(4):331-9. doi: 10.1111/j.1440-1681.1977.tb02670.x.

Clinical pharmacokinetics of methyldopa.

Clin Pharmacokinet. 1982 May-Jun;7(3):221-33. doi: 10.2165/00003088-198207030-00003.

Metabolism of methyldopa in man after oral administration of the pivaloyloxyethyl ester.

Drug Metab Dispos. 1984 Mar-Apr;12(2):242-6.

[Pharmacokinetics of alpha-methyldopa in kidney failure].

Klin Wochenschr. 1971 Dec 15;49(24):1329-34. doi: 10.1007/BF01495520.

引用本文的文献

Pharmacokinetics of the pivaloyloxyethyl (POE) ester of methyldopa, a new prodrug of methyldopa.

J Pharmacokinet Biopharm. 1982 Dec;10(6):587-600. doi: 10.1007/BF01062542.

Duration of effect of single daily dose methyldopa therapy.

Br J Clin Pharmacol. 1982 Jun;13(6):847-54. doi: 10.1111/j.1365-2125.1982.tb01877.x.

alpha-Methyldopa, alpha-methyldopamine an alpha-methylnoradrenaline: substrates for the thermolabile form of human platelet phenol sulphotransferase.

Br J Clin Pharmacol. 1982 Aug;14(2):231-9. doi: 10.1111/j.1365-2125.1982.tb01967.x.

Clinical pharmacokinetics of methyldopa.

Clin Pharmacokinet. 1982 May-Jun;7(3):221-33. doi: 10.2165/00003088-198207030-00003.

The absorption and conjugation of methyldopa in patients with coeliac and Crohn's diseases during treatment.

Br J Clin Pharmacol. 1983 Jul;16(1):77-83. doi: 10.1111/j.1365-2125.1983.tb02147.x.

The pharmacokinetics of alpha-methyldopa in dogs.

J Pharmacokinet Biopharm. 1985 Aug;13(4):405-23. doi: 10.1007/BF01061477.

Use of the peptide carrier system to improve the intestinal absorption of L-alpha-methyldopa: carrier kinetics, intestinal permeabilities, and in vitro hydrolysis of dipeptidyl derivatives of L-alpha-methyldopa.

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本文引用的文献

THE METABOLISM OF METHYLDOPA IN HYPERTENSIVE HUMAN SUBJECTS.

J Pharmacol Exp Ther. 1964 Feb;143:205-14.

STUDIES ON THE METABOLISM AND MECHANISM OF ACTION OF METHYLDOPA.

Circulation. 1963 Oct;28:492-502. doi: 10.1161/01.cir.28.4.492.

Methyldopa in hypertension. Clinical and pharmacological studies.

Lancet. 1962 Apr 14;1(7233):759-63. doi: 10.1016/s0140-6736(62)91781-6.

Combined clinical and metabolic study of the effects of alpha-methyldopa on hypertensive patients.

Circulation. 1966 Aug;34(2):308-21. doi: 10.1161/01.cir.34.2.308.

[Pharmacokinetics of alpha-methyldopa in kidney failure].

Klin Wochenschr. 1971 Dec 15;49(24):1329-34. doi: 10.1007/BF01495520.

Plasma turnover of methyldopa in advanced renal failure.

Acta Med Scand. 1972 Apr;191(4):343-7.

Hypotensive effect of methyldopa in renal failure associated with hypertension.

Acta Med Scand. 1972 Apr;191(4):333-7.

The renal excretion of methyldopa.

Scand J Clin Lab Invest. 1972 Apr;29(2):201-4. doi: 10.3109/00365517209081076.

Conjugation of methyldopa in renal failure.

Scand J Clin Lab Invest. 1972 Apr;29(2):195-9. doi: 10.3109/00365517209081075.

The metabolism of 14 C-labelled -methyldopa in normal and hypertensive human subjects.

Biochem J. 1972 Aug;129(1):1-10. doi: 10.1042/bj1290001.

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相似文献

Pharmacokinetics of methyldopa in healthy man.

Eur J Clin Pharmacol. 1977 Oct 14;12(2):117-23. doi: 10.1007/BF00645132.

Pharmacokinetics of methyldopa in man.

J Pharmacol Exp Ther. 1976 Aug;198(2):264-77.

The pharmacokinetics of alpha-methyldopa in dogs.

J Pharmacokinet Biopharm. 1985 Aug;13(4):405-23. doi: 10.1007/BF01061477.

Conjugation of methyldopa in renal failure.

Scand J Clin Lab Invest. 1972 Apr;29(2):195-9. doi: 10.3109/00365517209081075.

Pharmacokinetics and presystemic gut metabolism of methyldopa in healthy human subjects.

J Clin Pharmacol. 1995 Mar;35(3):275-80. doi: 10.1002/j.1552-4604.1995.tb04058.x.

The renal excretion of methyldopa.

Scand J Clin Lab Invest. 1972 Apr;29(2):201-4. doi: 10.3109/00365517209081076.

Pharmacokinetics of methyldopa. Plasma levels following single intravenous, oral and multiple oral dosage in normotensive and hypertensive subjects.

Clin Exp Pharmacol Physiol. 1977 Jul-Aug;4(4):331-9. doi: 10.1111/j.1440-1681.1977.tb02670.x.

Clinical pharmacokinetics of methyldopa.

Clin Pharmacokinet. 1982 May-Jun;7(3):221-33. doi: 10.2165/00003088-198207030-00003.

Metabolism of methyldopa in man after oral administration of the pivaloyloxyethyl ester.

Drug Metab Dispos. 1984 Mar-Apr;12(2):242-6.

[Pharmacokinetics of alpha-methyldopa in kidney failure].

Klin Wochenschr. 1971 Dec 15;49(24):1329-34. doi: 10.1007/BF01495520.

引用本文的文献

Pharmacokinetics of the pivaloyloxyethyl (POE) ester of methyldopa, a new prodrug of methyldopa.

J Pharmacokinet Biopharm. 1982 Dec;10(6):587-600. doi: 10.1007/BF01062542.

Duration of effect of single daily dose methyldopa therapy.

Br J Clin Pharmacol. 1982 Jun;13(6):847-54. doi: 10.1111/j.1365-2125.1982.tb01877.x.

alpha-Methyldopa, alpha-methyldopamine an alpha-methylnoradrenaline: substrates for the thermolabile form of human platelet phenol sulphotransferase.

Br J Clin Pharmacol. 1982 Aug;14(2):231-9. doi: 10.1111/j.1365-2125.1982.tb01967.x.

Clinical pharmacokinetics of methyldopa.

Clin Pharmacokinet. 1982 May-Jun;7(3):221-33. doi: 10.2165/00003088-198207030-00003.

The absorption and conjugation of methyldopa in patients with coeliac and Crohn's diseases during treatment.

Br J Clin Pharmacol. 1983 Jul;16(1):77-83. doi: 10.1111/j.1365-2125.1983.tb02147.x.

The pharmacokinetics of alpha-methyldopa in dogs.

J Pharmacokinet Biopharm. 1985 Aug;13(4):405-23. doi: 10.1007/BF01061477.

Pharm Res. 1989 Jan;6(1):66-70. doi: 10.1023/a:1015855820488.

本文引用的文献

THE METABOLISM OF METHYLDOPA IN HYPERTENSIVE HUMAN SUBJECTS.

J Pharmacol Exp Ther. 1964 Feb;143:205-14.

STUDIES ON THE METABOLISM AND MECHANISM OF ACTION OF METHYLDOPA.

Circulation. 1963 Oct;28:492-502. doi: 10.1161/01.cir.28.4.492.

Methyldopa in hypertension. Clinical and pharmacological studies.

Lancet. 1962 Apr 14;1(7233):759-63. doi: 10.1016/s0140-6736(62)91781-6.

Combined clinical and metabolic study of the effects of alpha-methyldopa on hypertensive patients.

Circulation. 1966 Aug;34(2):308-21. doi: 10.1161/01.cir.34.2.308.

[Pharmacokinetics of alpha-methyldopa in kidney failure].

Klin Wochenschr. 1971 Dec 15;49(24):1329-34. doi: 10.1007/BF01495520.

Plasma turnover of methyldopa in advanced renal failure.

Acta Med Scand. 1972 Apr;191(4):343-7.

Hypotensive effect of methyldopa in renal failure associated with hypertension.

Acta Med Scand. 1972 Apr;191(4):333-7.

The renal excretion of methyldopa.

Scand J Clin Lab Invest. 1972 Apr;29(2):201-4. doi: 10.3109/00365517209081076.

Conjugation of methyldopa in renal failure.

Scand J Clin Lab Invest. 1972 Apr;29(2):195-9. doi: 10.3109/00365517209081075.

The metabolism of 14 C-labelled -methyldopa in normal and hypertensive human subjects.

Biochem J. 1972 Aug;129(1):1-10. doi: 10.1042/bj1290001.