Reid C B, Snow G B, Brakenhoff R H, Braakhuis B J
John Hunter Hospital, Newcastle, New South Wales, Australia.
Aust N Z J Surg. 1997 Jul;67(7):410-6. doi: 10.1111/j.1445-2197.1997.tb02004.x.
Cytogenetic techniques for the analysis of genetic changes common in head and neck squamous cell carcinogenesis show complex patterns of chromosomal deletions, translocations, and amplifications. Powerful molecular biologic techniques have recently made possible the investigation of these abnormalities at the DNA level. Tumour suppressor gene loss and oncogene activation can now be recognized in tumours. Multiple genetic loci are implicated in the carcinogenesis process, while much evidence points to the existence of yet to be recognized tumour suppressor genes. An overview of the genetic changes commonly seen in head and neck squamous cell carcinogenesis and the possible implications of these are presented.
用于分析头颈部鳞状细胞癌发生过程中常见基因变化的细胞遗传学技术显示出染色体缺失、易位和扩增的复杂模式。强大的分子生物学技术最近使得在DNA水平上研究这些异常情况成为可能。现在可以在肿瘤中识别出肿瘤抑制基因的缺失和癌基因的激活。多个基因位点与致癌过程有关，同时有大量证据表明仍有未被识别的肿瘤抑制基因存在。本文对头颈部鳞状细胞癌发生过程中常见的基因变化及其可能的影响进行了综述。
