Schneider H R, Stadler P A, Stütz P, Troxler F, Seres J
Experientia. 1977 Nov 15;33(11):1412-3. doi: 10.1007/BF01918774.
The bromination of alpha-ergokryptine, a genuine ergot alkaloid of the peptide type, in position 2 of the indol nucleus to 2-bromo-alpha-ergokryptine is described. Its transformation to the methanesulfonate led to the prolactin inhibitor bromocriptine-methanesulfonate, Parlodel.
描述了肽类真正麦角生物碱α-麦角隐亭在吲哚核第2位溴化生成2-溴-α-麦角隐亭的过程。其转化为甲磺酸盐后得到催乳素抑制剂甲磺酸溴隐亭,即帕罗西汀。