Chatzimavroudis G P, Walker P G, Oshinski J N, Franch R H, Pettigrew R I, Yoganathan A P
Cardiovascular Fluid Mechanics Laboratory, School of Chemical Engineering, Georgia Institute of Technology, Atlanta 30332-0100, USA.
Ann Biomed Eng. 1997 Jul-Aug;25(4):644-52. doi: 10.1007/BF02684842.
Although several methods have been used clinically to evaluate the severity of aortic regurgitation, there is no purely quantitative approach for aortic regurgitant volume (ARV) measurements. Magnetic resonance phase velocity mapping can be used to quantify the ARV, with a single imaging slice in the ascending aorta, from through-slice velocity measurements. To investigate the accuracy of this technique, in vitro experiments were performed with a compliant model of the ascending aorta. Our goals were to study the effects of slice location on the reliability of the ARV measurements and to determine the location that provides the most accurate results. It was found that when the slice was placed between the aortic valve and the coronary ostia, the measurements were most accurate. Beyond the coronary ostia, aortic compliance and coronary flow negatively affected the accuracy of the measurements, introducing significant errors. This study shows that slice location is important in quantifying the ARV accurately. The higher accuracy achieved with the slice placed between the aortic valve and the coronary ostia suggests that this slice location should be considered and thoroughly examined as the preferred measurement site clinically.
尽管临床上已使用多种方法来评估主动脉瓣反流的严重程度，但对于主动脉反流容积（ARV）的测量尚无纯粹的定量方法。磁共振相速度映射可用于通过在升主动脉的单个成像切片上进行全切片速度测量来量化ARV。为了研究该技术的准确性，我们使用升主动脉顺应性模型进行了体外实验。我们的目标是研究切片位置对ARV测量可靠性的影响，并确定能提供最准确结果的位置。结果发现，当切片置于主动脉瓣和冠状动脉开口之间时，测量最为准确。在冠状动脉开口之外，主动脉顺应性和冠状动脉血流会对测量准确性产生负面影响，导致显著误差。本研究表明，切片位置对于准确量化ARV很重要。将切片置于主动脉瓣和冠状动脉开口之间可实现更高的准确性，这表明该切片位置应作为临床上首选的测量部位加以考虑并进行全面检查。
