Lephart E D, Watson M A, Rhees R W, Ladle D R, Jacobson N A
Department of Zoology, Brigham Young University, Provo, UT 84602, USA.
Neurosci Res. 1997 Jul;28(3):269-73. doi: 10.1016/s0168-0102(97)00043-6.
Developmental expression of calretinin in the medial basal hypothalamic (MBH) and amygdala region was examined by Western analysis. Males displayed significantly higher calretinin levels compared to females in the MBH (but not the amygdala) on gestational day 19 and 20. These data imply that hormonal factors may regulate developmental MBH calretinin expression. In turn, sexually dimorphic brain structures might be influenced by calretinin levels that can alter sexually dimorphic patterns of steroidogenesis, cellular migration or programmed cell loss mechanism(s) during neuronal development by modulating intracellular calcium concentrations.
通过蛋白质免疫印迹分析检测了钙视网膜蛋白在中脑基底下丘脑（MBH）和杏仁核区域的发育表达。在妊娠第19天和第20天，雄性MBH（而非杏仁核）中的钙视网膜蛋白水平显著高于雌性。这些数据表明，激素因素可能调节MBH钙视网膜蛋白的发育表达。反过来，性二态性脑结构可能受钙视网膜蛋白水平的影响，钙视网膜蛋白可通过调节细胞内钙浓度，在神经元发育过程中改变类固醇生成、细胞迁移或程序性细胞死亡机制的性二态性模式。
