丙硫氧嘧啶对大鼠由氧化偶氮甲烷诱导的肠道肿瘤形成的影响。
Effect of propylthiouracil on intestinal tumor formation by azoxymethane in rats.
作者信息
Singh D V, Campbell R L, Lin Y N, Nigro N D
出版信息
Experientia. 1977 Nov 15;33(11):1516-7. doi: 10.1007/BF01918844.
PMID:923732
Abstract
Treatment with propylthiouracil (PTU) resulted in a significant decrease in azoxymethane-induced intestinal tumors, total concentration of fecal bile acids as well as the fecal neutral steroids, cholesterol and coprostanol. Thus, a hypothyroid state induced by PTU treatment may affect intestinal carcinogenesis in this animal model by lowering the concentration of fecal bile acids and neutral steroids.
摘要
丙硫氧嘧啶（PTU）治疗导致氧化偶氮甲烷诱导的肠道肿瘤、粪便胆汁酸总浓度以及粪便中性类固醇、胆固醇和粪甾烷醇显著减少。因此，PTU治疗诱导的甲状腺功能减退状态可能通过降低粪便胆汁酸和中性类固醇的浓度来影响该动物模型中的肠道致癌作用。
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