将由禽白血病病毒长末端重复序列组成的串联直接重复序列插入1型马立克氏病病毒DNA的反向重复区域。
Insertion of tandem direct repeats consisting of avian leukosis virus LTR sequences into the inverted repeat region of Marek's disease virus type 1 DNA.
作者信息
Sakaguchi M, Sonoda K, Matsuo K, Zhu G S, Hirai K
机构信息
Chemo-Sero Therapeutic Research Institute, Kikuchi Research Center, Kumamoto, Japan.
出版信息
Virus Genes. 1997;14(2):157-62. doi: 10.1023/a:1007925519587.
The BC-1 strain DNA of Marek's disease virus type 1 (MDV1) at high-passage in culture was found to contain tandem direct repeats of the complete long terminal repeat (LTR) sequence of avian leukosis virus RAV0 strain as the repeat unit within the short inverted repeats of the MDV1 DNA. Since the attenuated BC-1 strain grows well in cultured cells, the insertion site for retroviral DNA sequence within the short inverted repeat of MDV1 DNA is not essential for viral growth in culture.
1型马立克氏病病毒（MDV1）在培养物中高传代的BC-1株DNA被发现，在MDV1 DNA的短反向重复序列内，含有禽白血病病毒RAV0株完整长末端重复（LTR）序列作为重复单元的串联直接重复序列。由于减毒的BC-1株在培养细胞中生长良好，MDV1 DNA短反向重复序列内逆转录病毒DNA序列的插入位点对于病毒在培养物中的生长不是必需的。
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