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使用胸廓内动脉进行单肺移植直接支气管动脉血运重建的中期结果(直接血运重建的单肺移植)

Medium term results of direct bronchial arterial revascularisation using IMA for single lung transplantation (SLT with direct revascularisation).

作者信息

Yacoub M, Al-Kattan K M, Tadjkarimi S, Eren T, Khaghani A

机构信息

Harefield Hospital, Middlesex, United Kingdom.

出版信息

Eur J Cardiothorac Surg. 1997 Jun;11(6):1030-6. doi: 10.1016/s1010-7940(96)01128-1.

Abstract

OBJECTIVE

To describe a technique of direct revascularisation of the bronchial artery using the left IMA and assess its medium term results in patients undergoing left single lung transplant (SLT).

METHODS

Between March 1991 and September 1993, 22 patients who underwent direct bronchial revascularisation at the time of left SLT (20 pedicled IMA, one free IMA, and one direct anastomosis to the aorta) have been followed up for a minimum period of 1 year (mean 30 +/- 12 months). Their mean age was 47.8 +/- 9.6 and the original disease was emphysema in 19, lymphangioleiomyomatosis in two, and pulmonary fibrosis in one. The mean ischaemia time was 269.7 +/- 23.4 min.

RESULTS

There was one early death (4.5%) and 3 patients were re-explored for bleeding. The actuarial survival at 1 and 3 years was 91 +/- 0.4% and 82.6 +/- 1%, respectively. Bronchial healing was excellent in all patients and angiographic studies showed patent vascular anastomosis in all 22 patients, with good run off in 20 and poor in two. One patient developed clinical obliterative bronchiolitis at 22 months (4.5%) during a period of follow up varying from 12 to 43 months (mean 30 S.D. 12). At last follow up the mean FEV1 was 1.4 +/- 0.4 and the mean FVC was 2.2 +/- 0.6. On average, each patient developed 1.5 +/- 0.6 infection episodes and 1 +/- 0.2 acute lung rejection.

CONCLUSION

It is concluded that the medium term results of direct bronchial revascularisation are good. However the influence of this procedure on long term results needs further investigation.

摘要

目的

描述一种使用左胸廓内动脉对支气管动脉进行直接血运重建的技术,并评估其在接受左单肺移植(SLT)患者中的中期结果。

方法

在1991年3月至1993年9月期间,对22例在左SLT时接受直接支气管血运重建的患者(20例带蒂胸廓内动脉、1例游离胸廓内动脉和1例与主动脉直接吻合)进行了至少1年的随访(平均30±12个月)。他们的平均年龄为47.8±9.6岁,原发病为肺气肿19例、淋巴管平滑肌瘤病2例、肺纤维化1例。平均缺血时间为269.7±23.4分钟。

结果

有1例早期死亡(4.5%),3例患者因出血接受再次手术探查。1年和3年的实际生存率分别为91±0.4%和82.6±1%。所有患者支气管愈合良好,血管造影研究显示所有22例患者血管吻合通畅,20例血流良好,2例血流不佳。1例患者在随访12至43个月(平均30标准差12)期间,于22个月时(4.5%)发生临床闭塞性细支气管炎。在最后一次随访时,平均第一秒用力呼气容积(FEV1)为1.4±0.4,平均用力肺活量(FVC)为2.2±0.6。平均而言,每位患者发生1.5±0.6次感染发作和1±0.2次急性肺排斥反应。

结论

得出直接支气管血运重建的中期结果良好的结论。然而,该手术对长期结果的影响需要进一步研究。

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