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[组胺和尼古丁对血管壁碳水化合物代谢指标及儿茶酚胺平衡的影响]

[Effect of histamine and nicotine on carbohydrate metabolic indices and the catecholamine balance in the vascular wall].

作者信息

Rachkov A K

出版信息

Farmakol Toksikol. 1977 Sep-Oct;40(5):563-9.

PMID:923779
Abstract

In experiments on cats subject to study was the effect of histamine and nicotine used in different doses on the level of "key" metabolites of the carbohydrate metabolism and on the catecholamines balance in the wall of vessels of different functional purpose at the instant of the maximum, bioelectric and motor response to a vasomotor agent. It was shown that the vasodilation phase observed after introduction of the mediatory type drugs was attended by activation of the carbohydrate metabolism this proving the energy-dependence of the relaxation process. The presence of variously oriented and differently marked changes in the content of the carbohydrate metabolites in vessels vessels of diverse functional purpose made it possible to classify the vessels according to the type of metabolism, which coincides with their functional purpose.

摘要

在对猫进行的实验中,研究了不同剂量的组胺和尼古丁对碳水化合物代谢“关键”代谢产物水平以及对不同功能用途血管壁中儿茶酚胺平衡的影响,实验时间为对血管舒缩剂产生最大生物电和运动反应的瞬间。结果表明,引入介导型药物后观察到的血管舒张期伴随着碳水化合物代谢的激活,这证明了舒张过程的能量依赖性。不同功能用途血管中碳水化合物代谢产物含量存在不同方向和不同程度的变化,这使得根据代谢类型对血管进行分类成为可能,而这种分类与它们的功能用途相符。

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