[Effect of a number of sulfur-containing radioprotective agents on the evacuatory function of the stomach in mice].

Tests staged on mongrel albino mice demonstrated that sulphur-containing radioprotectors used in doses two orders below those exercising a radioprotective action with their peroral administration are apt to significantly modify the evacuative function of the stomach. This properties of the sulphur-containing radioprotectors depends upon their chemical structure. A particularly strong influence on the evacuative function of the stomach in mice exerts cystamine dichlorohydrate, aminoalkylamino-alkylthiophosphates and mercaptoamidines. This property is less pronounced in cystaphos and cysteamine chlorhydrate. The least effect on the delayed evacuation was found in cysteamine bitartrate and in the disodium salt-4, 4(1)-trithiobis (butane-sulphonate). These data allow it to explain the specificity of the toxic and radioprotective action produced by diverse drugs with their peroral administration.