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[含硫辐射防护剂对肠上皮的保护作用机制]

[Mechanisms of the protective action of sulfur-containing radioprotectors on the intestinal epithelium].

作者信息

Vladimirov V G, Grigor'eva E V

出版信息

Radiobiologiia. 1990 May-Jun;30(3):348-52.

PMID:2164697
Abstract

In studying the influence of cystamine and gammaphos on the recovery of mouse jejunum epithelium after irradiation with doses inducing intestinal form of acute radiation sickness, it was shown that the radioprotective agents did not influence D0 value for intestinal epithelium stem cells, but in crypts the number of DNA-synthesizing enterocytes that entered mitosis increased after the preventive administration of the radioprotectors. All this caused the number of cells per villus to increase and intestinal mucosa to recover more readily.

摘要

在研究半胱胺和γ-磷对用诱导急性放射病肠型剂量照射后小鼠空肠上皮恢复的影响时发现,这些辐射防护剂对肠上皮干细胞的D0值没有影响,但在隐窝中,预防性给予辐射防护剂后进入有丝分裂的DNA合成肠上皮细胞数量增加。所有这些导致每个绒毛的细胞数量增加,肠黏膜更容易恢复。

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