Schreiner W, Neumann F, Neumann M, End A, Roedler S M
Department of Medical Computer Sciences, University of Vienna, Spitalgasse 23, Vienna, A-1090, Austria.
J Theor Biol. 1997 Jul 21;187(2):147-58. doi: 10.1006/jtbi.1997.0413.
The aim of this study was to investigate the extent that functional capability of vascular trees is related to anatomical variability. To these ends we used the method of Constrained Constructive Optimization (CCO) to generate optimized computer models of coronary arterial trees. All these model trees were optimized according to the same principle under equal boundary conditions of pressures and flows. However, by stochastically casting the locations of the terminal segments, different tree structures were generated, each of which conformed to the same boundary conditions. The structural variability of these models was interpreted as the correlate of the anatomical variability found in real arterial trees. The advantage that computer model trees are known in numerical detail was exploited to perform comprehensive and exact classifications of all segments into bifurcation levels, STRAHLER orders and composite vessels, and to compute the area expansion ratio. The unexpected result was that, despite striking visual differences in anatomical structure, the model trees were almost identical with regard to functional performance. We conclude that models optimized on the computer for a given perfusion task show little differences in their morphometric parameters even if they differ considerably regarding the course of the large vessels.
本研究的目的是调查血管树的功能能力与解剖变异的相关程度。为此，我们使用约束构造优化（CCO）方法生成冠状动脉树的优化计算机模型。所有这些模型树都在相同的压力和流量边界条件下，根据相同的原则进行优化。然而，通过随机确定末端节段的位置，生成了不同的树结构，每个结构都符合相同的边界条件。这些模型的结构变异被解释为真实动脉树中发现的解剖变异的相关因素。利用计算机模型树在数值细节上已知的优势，对所有节段进行全面而精确的分类，分为分叉水平、斯特拉勒等级和复合血管，并计算面积扩张率。出乎意料的结果是，尽管在解剖结构上存在明显的视觉差异，但模型树在功能性能方面几乎相同。我们得出结论，针对给定灌注任务在计算机上优化的模型，即使它们在大血管走行方面有很大差异，其形态计量学参数也几乎没有差异。
