短柄樟的生物碱。

Alkaloids of Ocotea brachybotra.

作者信息

Vecchietti V, Casagrande C, Ferrari G

出版信息

Farmaco Sci. 1977 Nov;32(11):767-9.

Abstract

Aporphine, proaporphine and morphinane alkaloids were isolated from the leaves of a Brazilian Lauracea, Ocotea brachybotra (Meiss.) Mez. The known alkaloids were identified through their physico-chemical properties as: (I) (+/-)-glaziovine, (II) dicentrine, (III) ocopodine, (IV) cassynthicine, (V) predicentrine, (VI) leucoxine, (IX) sinacutine and (X) pallidine. The structure of (VI) leucoxine was confirmed by a detailed analysis of the N.M.R. spectra recorded in various conditions. New morphinane alkaloids, (XI) ocobotrine and (XII) 14-espisinomenine, having the unusual B/C-trans configuration were also isolated. Their structures were determined using spectroscopic methods and chemical correlations.

摘要

从巴西樟科植物短柄桂（Ocotea brachybotra (Meiss.) Mez.）的叶子中分离得到了阿朴啡、原阿朴啡和吗啡烷类生物碱。通过物理化学性质鉴定出已知生物碱为：（I）（±）-格拉齐奥文、（II）双苄基异喹啉、（III）奥科波定、（IV）卡辛西辛、（V）前双苄基异喹啉、（VI）白屈菜碱、（IX）辛卡亭和（X）帕利定。通过对在各种条件下记录的核磁共振谱进行详细分析，确定了（VI）白屈菜碱的结构。还分离得到了具有不寻常的B/C-反式构型的新吗啡烷类生物碱，（XI）奥科波曲林和（XII）14-表异千金藤宁。利用光谱方法和化学关联确定了它们的结构。