番荔枝（Annona purpurea）中的抗血小板聚集成分。

Antiplatelet aggregation constituents from Annona purpurea.

作者信息

Chang F R, Wei J L, Teng C M, Wu Y C

机构信息

Graduate Institute of Natural Products, Kaohsiung Medical College, Kaohsiung, Taiwan, Republic of China, and Pharmacological Institute, College of Medicine, National Taiwan University, Taipei, Taiwan, Republic of China.

出版信息

J Nat Prod. 1998 Dec;61(12):1457-61. doi: 10.1021/np9800046.

DOI:10.1021/np9800046

PMID:9868142

Abstract

Bioactivity-directed fractionation led to the isolation of 19 compounds, including three oxoaporphines, oxopurpureine (5), oxonuciferine (6), and oxoglaucine (7); three aporphines, (+)-predicentrine (8), (-)-glaucine (9), and thalbaicalidine (10); one aporphine sensu stricto, N-formyl-purpureine (11); one proaporphine, glaziovine; one phenanthrene, thalicpureine (12); two 6a,7-dehydroaporphines, dehydrolirinidine (13) and 7-hydroxy-dehydroglaucine (14); four flavonoids, quercetin-3-O-rhamnoside, kaempferol-3-O-rhamnoside, isorhamnetin-3-O-rhamnoside, and tanarixetin-3-O-rhamnoside; one purine, adenine; one lactam amide, squamolone; and two steroids, beta-sitosterol and beta-sitosterol-beta-D-glucoside from the MeOH extract of the leaves of Formosan Annona purpurea. Among them, 11-14 were characterized as new compounds and alkaloids, 5-8, 10, and 12-14 exhibited significant antiplatelet aggregation activity.

摘要

生物活性导向分离法从台湾番荔枝叶的甲醇提取物中分离出19种化合物，包括三种氧化阿朴啡碱，氧化紫堇碱（5）、氧化荷叶碱（6）和氧化青藤碱（7）；三种阿朴啡碱，（+）-前降香碱（8）、（-）-青藤碱（9）和thalbaicalidine（10）；一种狭义阿朴啡碱，N-甲酰基紫堇碱（11）；一种原阿朴啡碱，glaziovine；一种菲，thalicpureine（12）；两种6a,7-脱氢阿朴啡碱，去氢荷叶碱（13）和7-羟基-脱氢青藤碱（14）；四种黄酮类化合物，槲皮素-3-O-鼠李糖苷、山柰酚-3-O-鼠李糖苷、异鼠李素-3-O-鼠李糖苷和柽柳素-3-O-鼠李糖苷；一种嘌呤，腺嘌呤；一种内酰胺酰胺，鳞茎酮；以及两种甾体，β-谷甾醇和β-谷甾醇-β-D-葡萄糖苷。其中，11-14被鉴定为新的化合物和生物碱，5-8、10以及12-14表现出显著的抗血小板聚集活性。