Valdes L, Champel V, Olivier C, Jonville-Bera A P, Autret E
Service de pédiatrie générale, hôpital Louis-Mourier, Colombes, France.
Arch Pediatr. 1997 Jun;4(6):535-7. doi: 10.1016/s0929-693x(97)87572-0.
Cardiotoxicity of cisapride may increase when this drug is associated with ranitidine.
A 37-day old term infant, treated with cisapride (1.2 mg/kg/d) and ranitidine for regurgitations, was hospitalized for malaise. A prolonged QT interval (with isolate ventricular extrasystoles), noted at admission, disappeared rapidly after cisapride withdrawal. Linkage to cisapride was probable, promoted by high dosage and cisapride metabolism inhibition by ranitidine, but its plasma concentration was not measured.
This case report stresses the problem of cisapride dosage in infants and the question of an interaction between cisapride and ranitidine.
西沙必利与雷尼替丁合用时，其心脏毒性可能会增加。
一名37日龄足月儿，因反流接受西沙必利（1.2毫克/千克/天）和雷尼替丁治疗，因不适住院。入院时发现QT间期延长（伴有孤立性室性早搏），停用西沙必利后迅速消失。可能与西沙必利有关，高剂量以及雷尼替丁对西沙必利代谢的抑制作用促使了这种情况发生，但未测定其血浆浓度。
本病例报告强调了婴儿西沙必利剂量问题以及西沙必利与雷尼替丁之间相互作用的问题。
