Golovleva I, Saha N, Beckman L
Department of Medical Genetics, Umeå University, Sweden.
Hum Hered. 1997 Jul-Aug;47(4):185-8. doi: 10.1159/000154411.
Interferon-alpha (IFN-alpha) is a protein family controlled by altogether 26 different IFN-alpha genes. We have previously described an SspI polymorphism in the IFN A17 gene and an association between the SspI A2 allele and nasopharyngeal cancer. In this paper we present data on ethnic differences with respect to IFN A17 SspI allele frequencies. Thus the frequency of the SspI A1 allele was high in two different Chinese populations (51 and 48%, respectively) and much lower (11%) in Swedes. Intermediate values were found in African Blacks (32%), Indians (25%), Saamis (29%) and Finns (24%). The very pronounced differences between major ethnic groups make the IFN A17 SspI polymorphism a very informative anthropological marker system and suggest that it may be balanced and maintained by natural selection.
α-干扰素（IFN-α）是一个由总共26个不同的IFN-α基因控制的蛋白质家族。我们之前描述过IFN A17基因中的SspI多态性以及SspI A2等位基因与鼻咽癌之间的关联。在本文中，我们呈现了关于IFN A17 SspI等位基因频率的种族差异数据。因此，SspI A1等位基因在两个不同的中国人群中的频率较高（分别为51%和48%），而在瑞典人中则低得多（11%）。在非洲黑人（32%）、印度人（25%）、萨米人（29%）和芬兰人（24%）中发现了中间值。主要种族群体之间非常显著的差异使得IFN A17 SspI多态性成为一个非常有信息量的人类学标记系统，并表明它可能通过自然选择达到平衡并得以维持。
