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一种25 kDa人类精子表面蛋白的定位:其在体外人类精子获能中的作用。

Localization of a 25 kDa human sperm surface protein: its role in in-vitro human sperm capacitation.

作者信息

Banerjee M, Chowdhury M

机构信息

Indian Institute of Chemical Biology, Calcutta, India.

出版信息

Mol Hum Reprod. 1997 Feb;3(2):109-14. doi: 10.1093/molehr/3.2.109.

DOI:10.1093/molehr/3.2.109
PMID:9239716
Abstract

A human endometrial sialic acid-binding glycoprotein (SABP) binds specifically to a 25 kDa protein on the plasma membranes of human non-capacitated sperm heads. In-vitro labelling of the sperm surface sialoglycoconjugates and subsequent incubation with SABP, suggests removal of some sialoglycoconjugate moieties from the sperm surface upon interaction with SABP. SABP also induces the exposure of mannose ligand receptors on the sperm surface and increases the production of superoxide anion (O2-).

摘要

一种人子宫内膜唾液酸结合糖蛋白(SABP)特异性结合人未获能精子头部质膜上的一种25 kDa蛋白。对精子表面唾液酸糖缀合物进行体外标记,随后与SABP一起孵育,结果表明,与SABP相互作用后,精子表面的一些唾液酸糖缀合物部分被去除。SABP还诱导精子表面甘露糖配体受体的暴露,并增加超氧阴离子(O2-)的产生。

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引用本文的文献

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Diversity of sialic acids and sialoglycoproteins in gametes and at fertilization.配子及受精过程中唾液酸和唾液酸糖蛋白的多样性。
Front Cell Dev Biol. 2022 Oct 20;10:982931. doi: 10.3389/fcell.2022.982931. eCollection 2022.
2
Sialic acid binding protein of human endometrium: its regulation by steroids.
Mol Cell Biochem. 2001 May;221(1-2):17-23. doi: 10.1023/a:1010901303113.