Nakajima Y, Yoshioka M, Mikami O, Arai S, Miyamoto S, Manda T, Yamanaka N, Hirose H, Motoi Y
National Institute of Animal Health, Tsukuba, Japan.
Vet Immunol Immunopathol. 1997 Jun;57(1-2):79-85. doi: 10.1016/s0165-2427(97)00001-9.
Ammoniated feed syndrome (AFS) in cattle is a neurotoxic syndrome caused by feeding specific ammoniated forage. To clarify the pathophysiology of AFS, we examined the association of interleukin-6 (IL-6) in the brain. By feeding milk either from cows fed such ammoniated forage or milk added with 4-methyl-imidazole, newborn calves showed a neurotoxic crisis of hyperexcitability, ataxia, muscle tremor, circling, roaring, epileptoid seizure, sweating and marked fever response. Although these calves had no pathological lesions in the brain, we detected a rise in IL-6 in the cerebrospinal fluid (CSF). Tumor necrosis factor-alpha (TNF-alpha) was not detected in the CSF. In the sera, IL-6 and TNF-alpha hardly changed during the experiment. Administration of recombinant human IL-6 into the lateral ventricle resulted in fever. Thus, we believe IL-6 in the CSF is related to the fever response in newborn calves with AFS.
牛的氨化饲料综合征（AFS）是一种由饲喂特定氨化草料引起的神经毒性综合征。为阐明AFS的病理生理学，我们研究了大脑中白细胞介素-6（IL-6）的关联。通过给新生犊牛饲喂来自食用此类氨化草料的母牛的牛奶或添加了4-甲基咪唑的牛奶，犊牛出现了过度兴奋、共济失调、肌肉震颤、转圈、吼叫、癫痫样发作、出汗和明显发热反应的神经毒性危机。尽管这些犊牛大脑中没有病理病变，但我们检测到脑脊液（CSF）中IL-6升高。脑脊液中未检测到肿瘤坏死因子-α（TNF-α）。在血清中，IL-6和TNF-α在实验期间几乎没有变化。向侧脑室注射重组人IL-6会导致发热。因此，我们认为脑脊液中的IL-6与患有AFS的新生犊牛的发热反应有关。
