Nĕmec J, Zamrazil V, Röhling S, Pohůnková D, Bednár J
Endokrinologie. 1979 Apr;74(1):81-9.
Plasma TSH levels were measured on 114 occasions in 96 patients treated for differentiated thyroid cancer. Prior to thyroid surgery, plasma TSH levels were within the range of normal. Plasma TSH levels increased slightly following partial thyroid resection and definitely after total thyroid ablation. In patients where the removal of normal thyroid induced hormonogenesis in thyroid tumours, plasma TSH levels were dependent on the hormonal secretion of the tumour as shown by inverse relationship between TSH and both PBI and 131I uptake. The increase of radioiodide uptake following stimulation by exogenous bovine TSH was inversely related to the plasma thyrotropin levels. The suppressibility of enhanced thyrotropin levels was complete with individually adjusted doses of synthetic thyroid hormones. With the exception of patients on suppressive treatment, TRH administration induced increase in plasma TSH levels. The findings are discussed with regard to the role played by TSH in the induction of hormonogenesis in thyroid tumours. The practical values of TSH estimation and TRH stimulation seem to be low; the measurements of thyrotropin levels may be important for the estimation of the suppressive effect in the course of and following withdrawal of treatment with thyroid hormones.
对96例分化型甲状腺癌患者进行了114次血浆促甲状腺激素（TSH）水平测定。甲状腺手术前，血浆TSH水平在正常范围内。部分甲状腺切除术后血浆TSH水平略有升高，全甲状腺切除术后则明显升高。在正常甲状腺切除导致甲状腺肿瘤发生激素生成的患者中，血浆TSH水平取决于肿瘤的激素分泌，TSH与蛋白结合碘（PBI）及131I摄取之间呈负相关即表明了这一点。外源性牛TSH刺激后放射性碘摄取的增加与血浆促甲状腺素水平呈负相关。使用个体化调整剂量的合成甲状腺激素可完全抑制升高的促甲状腺素水平。除接受抑制治疗的患者外，促甲状腺激素释放激素（TRH）给药可导致血浆TSH水平升高。就TSH在甲状腺肿瘤激素生成诱导中所起的作用对这些发现进行了讨论。TSH测定和TRH刺激的实际价值似乎较低；促甲状腺素水平的测定对于评估甲状腺激素治疗过程中及停药后的抑制效果可能很重要。
