Nedkova-Bratanova N, Ivanov E, Savov G, Michailova Z, Krusteva A, Petrova S
Enzyme. 1979;24(5):281-4. doi: 10.1159/000458676.
The intestinal dipeptidase and disaccharidase activities were investigated in 120 male albino rats of the Wistar strain after administration of 21 mumol.kg-1 body weight phosalone, 14.8 mumol.kg-1 body weight lindane and 10.5 mumol.kg-1 body weight phosalone combined with 7.4 mumol.kg-1 body weight lindane. The dipeptidase activity under the effect of these comparatively low doses of pesticides reveals slightly to moderate changes. The activity of intestinal disaccharidases after a 90-day phosalone and lindane treatment is markedly decreased, particularly that of sucrase. The mechanism of these changes remains unknown.
在给120只Wistar品系雄性白化大鼠分别给予21微摩尔/千克体重的伏杀磷、14.8微摩尔/千克体重的林丹以及10.5微摩尔/千克体重的伏杀磷与7.4微摩尔/千克体重的林丹组合后，对其肠道二肽酶和双糖酶活性进行了研究。这些相对低剂量农药作用下的二肽酶活性显示出轻微至中度变化。经过90天伏杀磷和林丹处理后，肠道双糖酶的活性显著降低，尤其是蔗糖酶。这些变化的机制尚不清楚。
