Stanley M A, Breckenridge J K, Swann A C, Freeman E B, Reich L
Department of Psychiatry and Behavioral Sciences, University of Texas Medical School, Houston, USA.
J Clin Psychopharmacol. 1997 Aug;17(4):278-83. doi: 10.1097/00004714-199708000-00007.
The present study examined the efficacy of fluvoxamine in the treatment of trichotillomania (TM) and coexistent clinical features. Twenty-one participants with a principal diagnosis of TM were given fluvoxamine in a 12-week open trial. For 13 patients who completed treatment, significant improvement was noted on only a few measures of hair pulling. End-state analyses for the entire group of participants, however, demonstrated significant improvement in measures of distress, duration, control, and resistance. Significant decreases over treatment were also found on measures of coexistent anxiety for both the completer and the entire participant groups; depressive symptoms improved for completers. Conclusions about the effectiveness of fluvoxamine for treatment of TM cannot be drawn, given the uncontrolled nature of the study; however, end-state analyses suggest the potential utility of fluvoxamine in a subset of patients with TM.
本研究考察了氟伏沙明治疗拔毛癖（TM）及共存临床特征的疗效。21名主要诊断为TM的参与者在一项为期12周的开放试验中接受了氟伏沙明治疗。对于13名完成治疗的患者，仅在少数拔毛测量指标上有显著改善。然而，对全体参与者的终末状态分析显示，在痛苦程度、持续时间、控制能力和抵抗能力的测量指标上有显著改善。在完成治疗者和全体参与者组中，共存焦虑测量指标在治疗期间也有显著下降；完成治疗者的抑郁症状有所改善。鉴于该研究的非对照性质，无法得出氟伏沙明治疗TM有效性的结论；然而，终末状态分析表明氟伏沙明在部分TM患者中可能有用。
