GGZ InGeest , Amsterdam , Netherlands ; Neuroscience Campus Amsterdam (NCA) , Amsterdam , Netherlands.
GGZ InGeest , Amsterdam , Netherlands ; Neuroscience Campus Amsterdam (NCA) , Amsterdam , Netherlands ; Department of Psychiatry, VU University Medical Center , Amsterdam , Netherlands ; Department of Anatomy and Neurosciences, VU University Medical Center , Amsterdam , Netherlands.
Front Hum Neurosci. 2014 Jun 11;8:419. doi: 10.3389/fnhum.2014.00419. eCollection 2014.
Over the past 20 years, motor response inhibition and interference control have received considerable scientific effort and attention, due to their important role in behavior and the development of neuropsychiatric disorders. Results of neuroimaging studies indicate that motor response inhibition and interference control are dependent on cortical-striatal-thalamic-cortical (CSTC) circuits. Structural and functional abnormalities within the CSTC circuits have been reported for many neuropsychiatric disorders, including obsessive-compulsive disorder (OCD) and related disorders, such as attention-deficit hyperactivity disorder, Tourette's syndrome, and trichotillomania. These disorders also share impairments in motor response inhibition and interference control, which may underlie some of their behavioral and cognitive symptoms. Results of task-related neuroimaging studies on inhibitory functions in these disorders show that impaired task performance is related to altered recruitment of the CSTC circuits. Previous research has shown that inhibitory performance is dependent upon dopamine, noradrenaline, and serotonin signaling, neurotransmitters that have been implicated in the pathophysiology of these disorders. In this narrative review, we discuss the common and disorder-specific pathophysiological mechanisms of inhibition-related dysfunction in OCD and related disorders.
在过去的 20 年中，由于运动反应抑制和干扰控制在行为和神经精神障碍的发展中起着重要作用，因此它们受到了相当多的科学关注。神经影像学研究的结果表明，运动反应抑制和干扰控制依赖于皮质-纹状体-丘脑-皮质（CSTC）回路。许多神经精神障碍，包括强迫症（OCD）和相关障碍，如注意力缺陷多动障碍、妥瑞氏症和拔毛癖，都报告了 CSTC 回路中的结构和功能异常。这些疾病也存在运动反应抑制和干扰控制的损伤，这可能是它们一些行为和认知症状的基础。这些疾病中抑制功能的任务相关神经影像学研究结果表明，受损的任务表现与 CSTC 回路的改变募集有关。先前的研究表明，抑制性能取决于多巴胺、去甲肾上腺素和血清素信号，这些神经递质与这些疾病的病理生理学有关。在这篇叙述性综述中，我们讨论了 OCD 和相关障碍中与抑制相关的功能障碍的共同和特定于疾病的病理生理机制。
