Acute myeloblastic leukemia associated with trisomy 8 and translocation 8;21 in a child with Down syndrome.
作者信息
Yamaguchi Y, Fujii H, Kazama H, Iinuma K, Shinomiya N, Aoki T
机构信息
Second Department of Pediatrics, Ohashi Hospital Toho University School of Medicine, Tokyo, Japan.
出版信息
Cancer Genet Cytogenet. 1997 Aug;97(1):32-4. doi: 10.1016/s0165-4608(96)00321-4.
PMID:9242215
Abstract
The present study examined an 11-year-old girl with Down syndrome who suffered from acute myeloblastic leukemia (AML) preceded by preleukemic pancytopenia. Chromosomal analysis of leukemic cells revealed a chromosome change at t(8;21) and trisomy 8 associated with constitutional trisomy 21. Treatment with antineoplastic agents led to complete remission.
摘要
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