Balogh E, Oláh E, Hunyadi K
Department of Pediatrics, Medical University of Debrecen, Hungary.
Cancer Genet Cytogenet. 1994 Aug;76(1):72-3. doi: 10.1016/0165-4608(94)90076-0.
A boy with Down syndrome who developed acute nonlymphocytic leukemia (ANLL/M2) at the age of 40 months is presented. Chromosomal analysis of cultured peripheral blood cells without mitogen revealed a constitutional abnormality, trisomy 21, associated with the acquired chromosome change t(8;21)(q22;q22).
本文报告一名40个月大患有唐氏综合征的男孩，其患急性非淋巴细胞白血病（ANLL/M2）。对未经有丝分裂原刺激的培养外周血细胞进行染色体分析，发现一种先天性异常，即21三体，伴有获得性染色体改变t(8;21)(q22;q22)。
