Bristot R, Santoro A, Fantozzi L, Delfini R
Department of Neurological Sciences, La Sapienza University of Rome, Italy.
Surg Neurol. 1997 Aug;48(2):160-3. doi: 10.1016/s0090-3019(97)00033-5.
The authors report a case of extra-axial cerebral cavernoma localized at the level of the cavernous sinus. This pathology is extremely rare, therefore, differential diagnosis with tumors such as meningioma is often difficult. During recent years, surgical indications for these lesions, congenital and rarely hereditary, have become more definite due to the considerable progress made in neuroradiologic and microsurgic techniques as well as better anatomic knowledge of this region.
This 49-year-old man was admitted with a 1-year history of diplopia. Cranial computed tomography (CT) scan with contrast medium, performed prior to admission, showed an expansive lesion at the level of the right cavernous sinus. Preoperative neuroradiologic diagnosis, after cerebral magnetic resonance imaging (MRI) with gadolinium enhancement and cerebral panangiography, was probable cavernoma. The lesion was totally removed via a fronto-orbito-temporo-zygomatic craniotomy.
Postoperatively, the patient had a right oculomotor nerve palsy. This spontaneously resolved 8 months after surgery; diplopia also completely disappeared. Early postoperative control MRI scans with gadolinium on the 2nd postoperative day and 3 months after operation confirmed total removal of the lesion.
The clinical onset and neuroradiologic aspect of these lesions and the fact that they rarely involve the cavernous sinus, may sometimes make preoperative diagnosis of cavernous sinus cavernoma difficult. Nevertheless, given the routine use of microsurgical techniques and improved anatomic knowledge of this delicate region, the treatment of choice is surgery. However, when doubts exist regarding achievement of total removal, radiosurgery is still a valid therapeutic tool.
作者报告一例位于海绵窦水平的轴外脑海绵状血管瘤病例。这种病理情况极为罕见,因此,与脑膜瘤等肿瘤的鉴别诊断往往很困难。近年来,由于神经放射学和显微外科技术取得了显著进展,以及对该区域解剖学知识的进一步了解,这些先天性且很少遗传性病变的手术指征变得更加明确。
该49岁男性因复视1年入院。入院前进行的头颅计算机断层扫描(CT)增强扫描显示右侧海绵窦水平有一占位性病变。经钆增强的脑磁共振成像(MRI)和脑血管造影术后,术前神经放射学诊断为可能的海绵状血管瘤。通过额眶颞颧开颅术将病变完全切除。
术后,患者出现右侧动眼神经麻痹。这在术后8个月自行缓解;复视也完全消失。术后第2天和术后3个月进行的早期钆增强MRI复查证实病变已完全切除。
这些病变的临床起病和神经放射学表现,以及它们很少累及海绵窦这一事实,有时可能使海绵窦海绵状血管瘤的术前诊断变得困难。然而,鉴于显微外科技术的常规应用以及对这个精细区域解剖学知识的改进,首选的治疗方法是手术。然而,当对是否实现完全切除存在疑问时,放射外科仍是一种有效的治疗手段。