De Franceschi L, Brugnara C, Beuzard Y
Department of Internal Medicine, University of Verona, Italy.
Blood. 1997 Aug 1;90(3):1283-90.
To ascertain the quantitative effect on the disease beta-thalassemia of a low-magnesium (Mg) diet compared with a high-Mg diet and a standard-Mg diet, we studied the effect these diets had over a 4-week period on beta-thalassemic (beta thal) mice compared with normal C57BL/6 mice used as controls. The low-Mg diet consisted of 6 +/- 2 mg Mg/kg body weight/d, the high-Mg diet 1,000 +/- 20 mg Mg/kg body weight/d, and the standard-Mg diet 400 +/- 20 mg Mg/kg body weight/d. Beta thal mice that were fed the low-Mg diet became more anemic, had reduced serum and erythrocyte Mg, and had decreased erythrocyte K. Their K-Cl cotransport increased, followed by commensurate cell dehydration. The high-Mg group showed a significant improvement of the anemia, increased serum and erythrocyte Mg, increased erythrocyte Mg, increased erythrocyte K, reduced K-Cl cotransport, and diminished cell dehydration. C57BL/6 control mice that received the low-Mg diet experienced anemia with erythrocyte dehydration, whereas the high-Mg diet had little effect on the hematologic parameters. Beta thal and C57BL/6 control mice that were fed a standard diet showed no changes. These results indicate that dietary Mg supplementation corrects hypomagnesemia and improves anemia in murine beta thal and should be assessed in human beta-thalassemia.
为确定低镁饮食与高镁饮食和标准镁饮食相比，对β地中海贫血疾病的定量影响，我们研究了这些饮食在4周时间内对β地中海贫血（β thal）小鼠的影响，并与用作对照的正常C57BL/6小鼠进行比较。低镁饮食含镁量为6±2毫克/千克体重/天，高镁饮食为1000±20毫克/千克体重/天，标准镁饮食为400±20毫克/千克体重/天。喂食低镁饮食的β thal小鼠贫血加重，血清和红细胞镁含量降低，红细胞钾含量减少。它们的钾氯共转运增加，随后细胞相应脱水。高镁组的贫血症状显著改善，血清和红细胞镁含量增加，红细胞镁含量增加，红细胞钾含量增加，钾氯共转运减少，细胞脱水减轻。接受低镁饮食的C57BL/6对照小鼠出现贫血并伴有红细胞脱水，而高镁饮食对血液学参数影响不大。喂食标准饮食的β thal和C57BL/6对照小鼠无变化。这些结果表明，饮食中补充镁可纠正小鼠β thal的低镁血症并改善贫血，应在人类β地中海贫血中进行评估。
