Breitenecker G
Fortschr Med. 1977 Dec 1;95(45):2737-42.
In 129 patients with sterility or endocrine menstrual cycle disturbances the pregnandiol concentrations in the urine were measured and in the same cycle the endometrium of the 1st day of menstruation histologically examined. The length of the corpus luteum phases was classified into 6 groups (over 14, 11--14, 9--10, 7--8, 1--6, 0 days), also the endometrial findings (over stimulated, normal, slightly, moderately, significantly retarded secretory transformation, no secretory signs). In 77.5% of the cases a complete accordance between the pregnandiol output and the endometrial biopsy was found, in 18% a difference of one step between the two parameters. Only in 4.5% great discrepancies were found, which partly could be explained by simultaneous medication in the same cycle. The two methods do not compete with each other but complete each other, because pregnandiol output is a parameter for corpus luteum function and endometrial histology reveals the reaction of the target organ to the hormonal stimulus. A statement about the etiology of the corpus luteum insufficiency is not possible by these two methods. For that further examination, i.a. serial evaluation of the sexual steroids and gonadotropins in serum are necessary.
对129例患有不育症或内分泌性月经周期紊乱的患者，测定其尿中孕二醇浓度，并在同一周期对月经第一天的子宫内膜进行组织学检查。黄体期的长度分为6组（超过14天、11 - 14天、9 - 10天、7 - 8天、1 - 6天、0天），同时记录子宫内膜的检查结果（过度刺激、正常、轻微、中度、显著延迟的分泌转化、无分泌迹象）。在77.5%的病例中，发现孕二醇排出量与子宫内膜活检结果完全相符，18%的病例中两个参数相差一个等级。仅4.5%的病例存在较大差异，部分原因可能是同一周期同时用药。这两种方法并非相互竞争，而是相互补充，因为孕二醇排出量是黄体功能的一个参数，而子宫内膜组织学显示了靶器官对激素刺激的反应。通过这两种方法无法对黄体功能不全的病因做出判断。为此需要进一步检查，例如对血清中性类固醇和促性腺激素进行系列评估。
