Guglielmi H, Jung A
Hoppe Seylers Z Physiol Chem. 1977 Nov;358(11):1463-8.
The synthesis and properties of 13 nucleosides derived from 5-aminoimidazole-4-carboxamide and from 4-aminoimidazole-5-carboxamide are described. The isomers were oriented by comparison of their spectra and colour reactions. All compounds were tested for anticancer activity. 4-Amino-1-(alpha-D-arabinopyranosyl)-imidazole-5-carboxamide significantly inhibits the growth of Ehrlich ascites carcinoma (fluid form) in mice.
描述了由5-氨基咪唑-4-甲酰胺和4-氨基咪唑-5-甲酰胺衍生的13种核苷的合成及其性质。通过比较它们的光谱和颜色反应确定异构体。对所有化合物进行了抗癌活性测试。4-氨基-1-(α-D-阿拉伯吡喃糖基)-咪唑-5-甲酰胺显著抑制小鼠艾氏腹水癌（腹水型）的生长。
