Johnson C B, Taylor P M
Department of Veterinary Clinical Medicine, University of Cambridge.
Res Vet Sci. 1997 Mar-Apr;62(2):159-63. doi: 10.1016/s0034-5288(97)90139-9.
Opioids have variable effects on the minimum alveolar concentration of inhaled anaesthetics in the horse. During halothane anaesthesia at an end-tidal halothane concentration between 0.75 and 0.85 percent, the electroencephalogram (EEG) frequency power spectrum and the auditory evoked potential were recorded continuously in eight ponies during an infusion of approximately 40 micrograms kg-1 alfentanil over five minutes, and for a further 55 minutes. The spectral edge and median frequency of the EEG and the mid-latency of the auditory evoked potential at the time of maximum change of these variables were compared with those recorded before the start of the infusion. The mean (SD) spectral edge and median frequencies were reduced by 26 (5) percent and 36 (6) percent respectively. The mid-latency of the auditory evoked potential did not change. These cortical effects of alfentanil in the horse are qualitatively the same as in other species, suggesting that the alfentanil-induced excitement observed in horses in not of cortical origin.
阿片类药物对马吸入麻醉药的最低肺泡浓度有不同影响。在异氟烷麻醉期间，当呼气末异氟烷浓度在0.75%至0.85%之间时，对8匹小马在5分钟内持续输注约40微克/千克阿芬太尼，并在随后的55分钟内连续记录脑电图（EEG）频率功率谱和听觉诱发电位。将这些变量最大变化时的脑电图频谱边缘和中位数频率以及听觉诱发电位的中潜伏期与输注开始前记录的进行比较。平均（标准差）频谱边缘和中位数频率分别降低了26（5）%和36（6）%。听觉诱发电位的中潜伏期没有变化。阿芬太尼在马身上的这些皮质效应在性质上与其他物种相同，这表明在马身上观察到的阿芬太尼诱发的兴奋并非源于皮质。
