Sylvester P A, Vipond M N, Kutt E, Davies J D, Webb A J, Farndon J R
Department of Surgery, Bristol Royal Infirmary, UK.
Ann R Coll Surg Engl. 1997 Jul;79(4):272-5.
The 4th year of the Avon breast screening programme comprises two distinct groups: those called for screening for the first time (prevalent group) and those who were initially screened 3 years earlier (incident group). The cancer detection rate, stage of disease and rate of interval cancers in these patients have been compared. For the prevalent groups of year 1 and year 4 there was no statistically significant difference in the cancer detection rate, proportion of small tumours or node positivity. For the prevalent and incident groups of year 4, there was no statistically significant difference in the cancer detection rate or proportion of small tumours. There were significantly fewer node-positive tumours in the incident group (5/45 vs 8/23; P < 0.05). Fifty-six interval cancers presented in the 3-year period between years 1 and 4 of screening; 28 (50%) after 24 months. The screening programme may result in tumours being detected at an earlier stage, but this may be offset by the high rate of interval cancers. This suggests that the time between screens may need to be reduced to 2 years.
雅芳乳腺筛查项目的第4年包括两个不同的群体：首次被要求进行筛查的人群（现患组）和3年前首次接受筛查的人群（新发病例组）。对这些患者的癌症检出率、疾病分期和间期癌发生率进行了比较。第1年和第4年的现患组在癌症检出率、小肿瘤比例或淋巴结阳性率方面没有统计学上的显著差异。第4年的现患组和新发病例组在癌症检出率或小肿瘤比例方面没有统计学上的显著差异。新发病例组中淋巴结阳性肿瘤明显较少（5/45对8/23；P<0.05）。在筛查的第1年至第4年的3年期间出现了56例间期癌；24个月后出现28例（50%）。筛查项目可能会使肿瘤在更早阶段被检测到，但这可能会被间期癌的高发生率所抵消。这表明筛查间隔时间可能需要缩短至2年。
