Schander K, Wahl W, Rehm A
Fortschr Med. 1979 Oct 11;97(38):1696-702.
In a group of 20 women 22 parameters of the blood coagulation and fibrinolysis systems were separately determined during spontaneous delivery. An increased activity of the coagulation factors was observed except of the factors V, IX and XIII. Factor VIII activity in plasma increased slightly during stage II of labour, probably related to stress. Fibrinogen as well as the factors II, VII and X exhibited congruently slight post partum decrease, which can be interpreted as the result of an increased turnover of these factors. Plasminogen levels as well as antiplasmin activity increased; the total fibrinolysis activity was not significantly changed. The increase of fibrin-fibrinogen degradation products, however, indicated the occurrence of discrete fibrinolytic or fibrinogenolytic reactions. The thrombelastograms demonstrated a shift of the balance of pro- and anticoagulatory factors in favour of an increased blood coagulation activity during labour.
在一组20名产妇自然分娩过程中，分别测定了血液凝固和纤维蛋白溶解系统的22项参数。除因子V、IX和XIII外，观察到凝血因子活性增加。分娩第二阶段血浆中因子VIII活性略有增加，可能与应激有关。纤维蛋白原以及因子II、VII和X产后均呈现一致的轻微下降，这可解释为这些因子周转率增加的结果。纤溶酶原水平以及抗纤溶酶活性增加；总纤维蛋白溶解活性无明显变化。然而，纤维蛋白-纤维蛋白原降解产物的增加表明发生了离散的纤维蛋白溶解或纤维蛋白原溶解反应。血栓弹力图显示，分娩期间促凝和抗凝因子平衡发生变化，有利于血液凝固活性增加。
