González-Pinto A, López-Ibor J J, Sáiz J, Gutiérrez M, Figuerido J L, Elizagárate E, Pérez de Heredia J L
Hospital Santiago Apóstol. Vitoria.
Actas Luso Esp Neurol Psiquiatr Cienc Afines. 1997 Mar-Apr;25(2):73-8.
This study employed an alternative method for assessing serotonergic function in depression. The neuroendocrine responses to acute intravenous administration of the serotonin (5-HT) reuptake inhibitor clomipramine were assessed in patients with Major Depression with Melancholia (DMM) and matched subjects with Major Depression (DM) (without Melancholia) and Dysthimic disorder (TD).
10 patients who met DSM III-R criteria of DMM, 10 patients with DM and 10 with DD matched for age and sex received 12.5 mg of intravenously administered clomipramine. Prl, Cortisol and GH were measured during the next 135 minutes. We divided the samples using the Newcastle Scale.
The DMM patients had significant blunting prolactin responses to clomipramine compared with the other patients. Most of the major depression patients without melancholia were neurotic depressions according to the Newcastle Scale. There was a negative correlation between endogeneity and prolactin response.
These data support the hypothesis that DMM patients have abnormal neuroendocrine responses to the intravenous administration of the 5-HT reuptake inhibitor clomipramine, and that there is an association between endogeneity and prolactin response.
本研究采用一种替代方法评估抑郁症患者的血清素能功能。对伴有忧郁症的重度抑郁症（DMM）患者、匹配的重度抑郁症（DM）（无忧郁症）患者及恶劣心境障碍（TD）患者，评估其对急性静脉注射血清素（5-HT）再摄取抑制剂氯米帕明的神经内分泌反应。
10名符合DMM的DSM III-R标准的患者、10名DM患者及10名TD患者（年龄和性别匹配）接受12.5mg静脉注射氯米帕明。在接下来的135分钟内测量催乳素（Prl）、皮质醇和生长激素（GH）。我们使用纽卡斯尔量表对样本进行划分。
与其他患者相比，DMM患者对氯米帕明的催乳素反应明显迟钝。根据纽卡斯尔量表，大多数无忧郁症的重度抑郁症患者为神经性抑郁症。内源性与催乳素反应之间存在负相关。
这些数据支持以下假设，即DMM患者对静脉注射5-HT再摄取抑制剂氯米帕明有异常的神经内分泌反应，且内源性与催乳素反应之间存在关联。
