Anderson I M, Ware C J, da Roza Davis J M, Cowen P J
University Department of Psychiatry, Littlemore Hospital, Oxford.
Br J Psychiatry. 1992 Mar;160:372-8. doi: 10.1192/bjp.160.3.372.
The prolactin response to intravenous clomipramine, a 5-HT uptake inhibitor, was significantly attenuated in 12 patients with major depression. In contrast, in a further 12 depressed patients, the PRL responses to thyrotropin-releasing hormone, which acts directly on the pituitary to release PRL, were not reduced. These findings suggest that the reduction in 5-HT-mediated PRL release seen in depressed patients is due to an impairment of brain 5-HT function rather than a pituitary abnormality.
在12例重度抑郁症患者中，催乳素对静脉注射氯米帕明（一种5-羟色胺摄取抑制剂）的反应显著减弱。相比之下，在另外12例抑郁症患者中，催乳素对促甲状腺激素释放激素（直接作用于垂体释放催乳素）的反应并未降低。这些发现表明，抑郁症患者中5-羟色胺介导的催乳素释放减少是由于脑5-羟色胺功能受损，而非垂体异常。
