Chaudhuri S, Bhaumik K
Theory Group, Saha Institute of Nuclear Physics, 1/AF Bidhannagar, Calcutta, 700064, India.
J Theor Biol. 1997 Aug 7;187(3):351-62. doi: 10.1006/jtbi.1997.0444.
Release of transmitter substances during synaptic communication in a biological process of great importance, and it is worthwhile to ascertain the basic molecular events underlying this process. We present a minimal model of synaptic vesicle (SV) dynamics, with which most of the major experimentally observed features of evoked neurotransmitter release can be reproduced. The effect of different parameters on the time course of evoked release as well as the effect of repetitive stimulation on this model system has been examined.
在突触通讯过程中释放递质是一个极其重要的生物学过程，确定这一过程背后的基本分子事件是值得的。我们提出了一个突触小泡（SV）动力学的最小模型，利用该模型可以重现诱发神经递质释放的大多数主要实验观察特征。我们研究了不同参数对诱发释放时间进程的影响以及重复刺激对该模型系统的影响。
