Outschoorn I M
Immunology. 1979 Oct;38(2):225-34.
Idiotypic antibodies were prepared by immunizing two groups of rabbits with dextran-antidextran specific precipitates and purified antidextran obtained subsequently from the same human donor. Half of the animals were made tolerant to pooled human IgG. Tests showed that sera from tolerant rabbits reacted better with the antidextran preparation used to immunize the other group of animals than with the antidextran that formed part of their immunogen. Non-tolerant animals did not recognize this serological difference. Sera from animals immunized with the antidextran preparation donated later reacted better with this material irrespective of their tolerance to human IgG.
通过用葡聚糖 - 抗葡聚糖特异性沉淀物和随后从同一人类供体获得的纯化抗葡聚糖免疫两组兔子来制备独特型抗体。其中一半动物对混合人IgG产生耐受。测试表明，耐受兔子的血清与用于免疫另一组动物的抗葡聚糖制剂反应，比与构成其免疫原一部分的抗葡聚糖反应更好。未耐受的动物未识别出这种血清学差异。用后来捐赠的抗葡聚糖制剂免疫的动物血清，无论它们对人IgG的耐受性如何，都与该物质反应更好。
